The Role of CGRP Monoclonal Antibodies in the Treatment of Acute Cluster Headache

This article discusses the role of Calcitonin Gene-Related Peptide antagonists available on market in treating cluster headaches. All treatments discussed this focus either abortive, preventive, or transitional care. These therapies include Monoclonal Antibodies (Galcanezumab, Fremanezumab, Erenumab), high-flow oxygen, triptans (sumatriptan, zolmitriptan), Octreotide, non-invasive vagus nerve stimulation (vagus and sphenopalatine nerves), other medications like dihydroergotamine, lidocaine, capsaicin. We reviewed many studies from The United States since 2015; analytical methods were utilized. Moreover, we found that some treatment options for CH can vary depending efficacy route administration according to categories therapy (acute preventive). Every has a specific unique mechanism action, indications, contraindications, side effects. Therefore, recommendation one particular should be considered success Cluster Headaches. against CGRP have are first alternative acute CH.